RESUMEN El presente artículo está dirigido a sistematizar una concepción teórica y metodológica que sustente el proceso de extensión universitaria en la carrera de Medicina en Cuba. Entre los resultados se destaca el lugar y papel de la extensión universitaria en el sistema de la formación integral del profesional a la que se asigna una connotación especial, de marcado contenido axiológico, coherente con las necesidades y proyecciones sociales que facilita la formación del educando y fortalece la relación institución-comunidad. Es factible (...) de ser aplicado pues puede devenir en una importante contribución a elevar el impacto social de la docencia médica en tanto atiendan aspectos como la preparación de los implicados en las diferentes instancias; la colaboración de los consejos populares y los factores de la comunidad que se manifiestan en el modo de actuación del profesional. ABSTRACT The present article is directed to systematize a theoretical and methodological conception that sustains the process of university extension in the career of Cuban medicine. Among the results he/she stands out the place and paper of the university extension in the system of the integral formation from the professional to which a special connotation is assigned, of marked axiological contained, coherent with the necessities and social projections that it facilitates the formation of the educating and it strengthens the relationship institution-community. It is feasible of being applied then it can become in an important contribution to elevate the social impact of the medical teaching as long as they assist aspects like the preparation of those implied in the different instances; the collaboration of the popular advice and the factors of the community that are manifested in the way of the professional's performance. (shrink)

Despite the promises made by molecular evolutionists since the early 1960s that phylogenies would be readily reconstructed using molecular data, the construction of molecular phylogenies has both retained many methodological problems of the past and brought up new ones of considerable epistemic relevance. The field is driven not only by changes in knowledge about the processes of molecular evolution, but also by an ever-present methodological anxiety manifested in the constant search for an increased objectivity—or in its converse, the avoidance of (...) subjectivity.This paper offers an exhaustive account of the methodological and conceptual difficulties embedded in each of the steps required to elaborate molecular phytogenies. The authors adopt a historical perspective on the field in order to follow the development of practices that seek to increase the objectivity of their methods and representations. These include the adoption and development of explicit criteria for evaluation of evidence, and of procedures associated with methods of statistical inference, quantification and automation. All these are linked to an increasing use of computers in research since the mid 1960s. We will show that the practices of objectivity described are highly dependent on the problems and tools of molecular phylogenetics. (shrink)

This paper focuses on the consolidation of Molecular Evolution, a field originating in the 1960s at the interface of molecular biology, biochemistry, evolutionary biology, biophysics and studies on the origin of life and exobiology. The claim is made that Molecular Evolution became a discipline by integrating different sorts of scientific traditions: experimental, theoretical and comparative. The author critically incorporates Timothy Lenoir’s treatment of disciplines , as well as ideas developed by Stephen Toulmin on the same subject. On their account disciplines (...) are spaces where the social and epistemic dimensions of science are deeply and complexly interwoven. However, a more detailed account of discipline formation and the dynamics of an emerging disciplinary field is lacking in their analysis. The present essay suggests focusing on the role of scientific concepts in the double configuration of disciplines: the social/political and the epistemic order. In the case of Molecular Evolution the concepts of molecular clock and informational molecules played a central role, both in differentiating molecular from classical evolutionists, and in promoting communication between the different sorts of traditions integrated in Molecular Evolution. The paper finishes with a reflection on the historicity of disciplines, and the historicity of our concepts of disciplines. (shrink)

The use of molecules and reactions as evidence, markers and/or traits for evolutionary processes has a history more than a century long. Molecules have been used in studies of intra-specific variation and studies of similarity among species that do not necessarily result in the analysis of phylogenetic relations. Promoters of the use of molecular data have sustained the need for quantification as the main argument to make use of them. Moreover, quantification has allowed intensive statistical analysis, as a condition and (...) a product of increasing automation. All of these analyses are subject to the methodological anxiety characteristic of a community in search of objectivity. It is in this context that scientists compared and evaluated protein and nucleic acid sequence data with other types of molecular data – including immunological, electrophoretic and hybridization data. This paper argues that by looking at long-term historical processes, such as the use of molecular evidence in evolutionary biology, we gain valuable insights into the history of science. In that sense, it accompanies a growing concern among historians for big-pictures of science that incorporate the fruitful historical research on local cases of the last decades. (shrink)

Between December 14 and 20, 1965, the World Health Organization Scientific Group on Haemoglobinopathies and Allied Disorders metatthe Geneva agency's headquarters. The group comprised eight well-known physicians including Tulio Arends, a leading Latin American human geneticist from the Venezuelan Institute for Scientific Investigations. Others came from North America, Northern and Southern Europe, the Middle East and South East Asia, an array that reflected the delicate geopolitical equilibriums of postwar international health programs, but also the development of highly specialized biomedical research (...) around the globe. They elected Herman Lehmann, from the Abnormal Haemoglobin Research Unit of the Medical Research... (shrink)

This paper extends previous arguments against the assumption that the study of variation at the molecular level was instigated with a view to solving an internal conflict between the balance and classical schools of population genetics. It does so by focusing on the intersection of basic research in protein chemistry and the molecular approach to disease with the enactment of global health campaigns during the Cold War period. The paper connects advances in research on protein structure and function as reflected (...) in Christian Anfinsen’s The molecular basis of evolution, with a political reading of Emilé Zuckerkandl and Linus Pauling’s identification of molecular disease and evolution. Beyond atomic fallout, these advances constituted a rationale for the promotion of genetic surveys of human populations in the Third World, in connection with international health programs. Light is shed not only on the experimental roots of the molecular challenge but on the broader geopolitical context where the rising role of biomedicine and public health had an impact on evolutionary biology. (shrink)

ArgumentThis paper explores the connection between the epistemic and the “political” dimensions of the metaphor of information during the early days of the study of Molecular Evolution. While preserving some of the meanings already documented in the history of molecular biology, the metaphor acquired a new, powerful use as a substitute for “history.” A rhetorical analysis of Emilé Zuckerkandl's paper, “Molecules as Documents of Evolutionary History,” highlights the ways in which epistemic claims on the validity and superiority of molecular evidence (...) for evolution were intimately connected with authority issues in evolutionary biology. The debate is situated within the framework of the battle for resources between traditional evolutionists and molecular biologists at the beginning of the 1960s. The architects of evolutionary synthesis questioned the idea that molecular characters constitute “cleaner” and “more direct” evidence of evolution. Nevertheless, the information discourse constituted a productive space for the development of a new research program that, paradoxically, has made explicit the limitations of the information metaphor in reconstructing life's history. (shrink)

In this special issue we explore practices of scientific inquiry into human populations in Latin America in order to generate new insights into the complex historical and sociopolitical dynamics that have made certain human groups integral to the production of scientific knowledge in and about the region. In important contributions, other scholars have shown that the science of human difference is racist and all too often has been a mediator of development ideologies. To further unpack these arguments we focus attention (...) on the complex interaction between scientists and the populations they study. We explore cases from across the fields of evolutionary biology, demography, epidemiology... (shrink)

This paper argues that the “long 1970s” (1969–1983) is an important though often overlooked period in the development of a rich landscape in the research of metabolism, development, and evolution. The period is marked by: shrinking public funding of basic science, shifting research agendas in molecular biology, the incorporation of new phenomena and experimental tools from previous biological research at the molecular level, and the development of recombinant DNA techniques. Research was reoriented towards eukaryotic cells and development, and in particular (...) towards “giant” RNA processing and transcription. We will here focus on three different models of developmental regulation published in that period: the two models of eukaryotic genetic regulation at the transcriptional level that were developed by Georgii P. Georgiev on the one hand, and by Roy Britten and Eric Davidson on the other; and the model of genetic sufficiency and evolution of regulatory genes proposed by Emile Zuckerkandl. These three cases illustrate the range of exploratory hypotheses that characterised the challenging landscape of gene regulation in the 1970s, a period that in hindsight can be labelled as transitional, between the biology at the laboratory bench of the preceding period, and the biology of genetic engineering and intensive data-driven research that followed. (shrink)

English possessives with apostrophe mark.

Berichte zur Wissenschaftsgeschichte, Volume 45, Issue 3, Page 332-343, September 2022.

Berichte zur Wissenschaftsgeschichte, Volume 45, Issue 3, Page 332-343, September 2022.

During the IAEA’s Mobile Radioisotope Exhibition (1960–1965) through the eventful roads of five Latin American countries (Mexico, Uruguay, Argentina, Brazil, and Bolivia), a variety of photographs were taken by an unknown Mexican official photographer, and by Josef Obermayer, a staff driver from Vienna. The exhibition carried not only bits of nuclear sciences and technologies, but also the political symbolism of the ‘friendly atom’ as a token of modernization. The photographs embarked on different trajectories, though all of them ended up at (...) the training and exchange official’s desk in charge of the exhibition, Argentinian physicist Arturo Cairo. The ones taken in Mexico also had a local circulation as propaganda intended to promote radioisotope applications. The two sets of images were intended to show the contrast between modernity and traditional society, but they did it from different gazes. Our paper argues that, in the case of Mexico, the photographer reinforced representations of the country which were already popularized by Hollywood for foreign and local audiences. On the other hand, the Viennese photographer’s gaze delivers an autoethnography of his dutiful journey. We also argue that Obermayer’s projection is one of what Roger Bartra has conceptualized as the ‘salvage on the mirror’. (shrink)

Adaptive optics are techniques used for processing the spatial resolution of astronomical images taken from large ground-based telescopes. In this work, computational results are presented for a modified curvature sensor, the tomographic pupil image wavefront sensor, which measures the turbulence of the atmosphere, expressed in terms of an expansion over Zernike polynomials. Convolutional neural networks are presented as an alternative to the TPI-WFS reconstruction. This technique is a machine learning model of the family of artificial neural networks, which are widely (...) known for its performance as modeling and prediction technique in complex systems. Results obtained from the reconstruction of the networks are compared with the TPI-WFS reconstruction by estimating errors and optical measurements. The reconstructed wavefronts from both techniques are compared for wavefronts of 153 Zernike modes. For this case, a detailed comparison and grid search to find the most suitable neural network is performed, searching between multi-layer perceptron, CNN and recurrent networks topologies. In general, the best network was a CNN trained for TPI-WFS reconstruction, achieving better performance than the reconstruction software from TPI-WFS in most of the turbulent profiles, but the most significant improvements were found for higher turbulent profiles that have the lowest r0 values. (shrink)

Reconstructing the genetic traits of the Last Common Ancestor and the Tree of Life are two examples of the reaches of contemporary molecular phylogenetics. Nevertheless, the whole enterprise has led to paradoxical results. The presence of Lateral Gene Transfer poses epistemic and empirical challenges to meet these goals; the discussion around this subject has been enriched by arguments from philosophers and historians of science. At the same time, a few but influential research groups have aimed to reconstruct the LCA with (...) rich-in-detail hypotheses and high-resolution gene catalogs and metabolic traits. We argue that LGT poses insurmountable challenges for detailed and rich in details reconstructions and propose, instead, a middle-ground position with the reconstruction of a slim LCA based on traits under strong pressures of Negative Natural Selection, and for the need of consilience with evidence from organismal biology and geochemistry. We defend a cautionary perspective that goes beyond the statistical analysis of gene similarities and assumes the broader consequences of evolving empirical data and epistemic pluralism in the reconstruction of early life. (shrink)

ArgumentThis paper analyzes the research strategies of three different cases in the study of human genetics in Mexico – the work of Rubén Lisker in the 1960s, INMEGEN's mapping of Mexican genomic diversity between 2004 and 2009, and the analysis of Native American variation by Andrés Moreno and his colleagues in contemporary research. We make a distinction between an approach that incorporates multiple disciplinary resources into sampling design and interpretation (unpacking), from one that privileges pragmatic considerations over more robust multidisciplinary (...) analysis (flattening). These choices have consequences for social, demographic, and biomedical practices, and also for accounts of genetic variation in human populations. While the former strategyunpacksfine-grained genetic variation – favoring precision and realism, the latter tends toflattenindividual differences and historical depth in lieu of generalization. (shrink)

In the fiftieth disputation of his Disputationes metaphysicae (1597), Francisco Suárez distinguishes three notions of time. Suárez offers an account of the ways in which the predicate ‘when’ can be taken and presents a more general perspective based on the principle of duration, rather than the Aristotelian definition of time. His view differs from Aristotle’s and Aquinas’ account because Suárez emphasizes that time cannot be reduced to the number of the movement of the last sphere in the (...) Aristotelian model of the cosmos. The intrinsic duration of a thing is its true time; this duration can be taken in an absolute or a relative sense. In an absolute sense, intrinsic time is an internal property of a thing that cannot be really distinguished from existence itself and cannot be compared with other durations. In a relative sense, we can imagine this intrinsic duration as filling up a certain interval within an infinitely extended imaginary succession. This imaginary succession is an ens rationis. The third concept of time is the Aristotelian notion: this is just an extrinsic time, a measurement of one movement by means of a comparison with another movement, especially the motion of the last sphere. Finally, in order to show the value of Suárez’s insights, I compare them with some contemporary issues in the analytic philosophy of time. (shrink)

T echnocrati c fundamentalis m (neocons ) an d theocrati c fundamentalis m (teocons) ar e t w o manifestation s o f politica l though t v e r y restrict i v e o f democra c y . Th e f irst on e ha s a highe r incidenc e i n th e f iel d o f econo m y an d th e secon d on e i n tha t o f the (...) religion , bu t bot h imp l y a stron g challeng e fo r th e democrati c State . Thi s a r ticl e deals wit h th e mor e o r les s fo r ma l conjunctio n bet w ee n bot h kind s o f fundamentalism , that appear s an d acts , e v e n a t a globa l l e v el , a s a v e r y conse r v at i v e reactio n agains t the mai n demand s o f c i vi c laicis m an d o f pr o g ress i v e policies . Th e autho r maintain s that th e an s w e r t o thes e n e w fundamentalisms , li k e t o th e ol d d o gmatisms , i s no t a t all th e relat i vism , bu t th e critica l an d aut o critica l thought . Th e poin t i s t o ad v ance , with thi s critica l attitude , i n th e const r uctio n o f n e w democrati c fo r mulations , pr o vided wit h a mor e stron g fundamen t i n te r m s o f ethica l l e gitima c y an d socia l l e gitimation. (shrink)

El presente artículo pretende sintetizar las líneas maestras del Barroco como época histórica y filosófica. El objetivo es mostrar la importancia del Barroco como momento histórico genuinamente español, centrando la relevancia de autores como Suárez y, sobre todo, Gracián, quienes anticipan en cierto sentido alguna de las problemáticas filosóficas del siglo XX como son la posmodernidad, la crisis de valores o la ontología eventual (factual). Se trata, en último término, de reivindicar el pensamiento español y la lengua española como (...) vehículos genuinos para pensar la actualidad. (shrink)

El presente trabajo se propone ofrecer una panorámica general de un tema que ha sido, es y seguirá siendo polémico: la responsabilidad penal de los menores. Para lograr dicho objetivo se dará cuenta de la regulación vigente al respecto, la que hasta llegar a la situación actual ha debido recorrer un largo camino de reformas que serán revisadas en algunos de sus aspectos más controvertidos. Asimismo se fundamentará el indudable carácter penal de la LO 5/2000, de 12 de enero, reguladora (...) de la responsabilidad penal de los menores, de las medidas que impone y, en consecuencia, de la responsabilidad que se exige a los menores sometidos a ella. Parte importante de este artículo estará dedicada, de un lado, a estos menores de entre 14 y 18 años destinatarios de la LO 5/2000, respecto de los que, entre otras cuestiones, se determinará si son o no imputables; y, de otro, a aquellos que tienen menos de 14 años, reflexionando, entre otros extremos, sobre la necesidad o no de rebajar dicha edad como límite mínimo para comenzar a exigir responsabilidad criminal. (shrink)

El tratamiento dispensado al hecho religioso en nuestro país y en general en las sociedades avanzadas es discriminatorio respecto a otros colectivos y grupos sociales. Discriminatorio en una dimensión interna y externa. Internamente, porque no todos los grupos religiosos reciben el mismo trato jurídico. Externamente, porque otros grupos sociales distintos a los religiosos, que buscan otros fines, no reciben el mismo trato que los grupos religiosos, sino más desfavorable. Junto a una primera discriminación en el ámbito extraeclesial -el de las (...) confesiones religiosas en su relación con las demás asociaciones del país-, hay otros dos supuestos en el ámbito intraeclesial -el de las relaciones de los grupos religiosos entre sí-, el contraste de las opciones fideístas y las no fideístas críticas y el de las confesiones religiosas mayoritarias y minoritarias. En uno y otro caso, interna y externamente, el hecho religioso se convierte en un criterio de discriminación, sin que en mi opinión existan razones objetivas suficientes. (shrink)

E l auto r de f iend e un a democraci a a r mónica , qu e n o e s u n model o nu ev o d e democracia sin o l a relació n equilibrad a d e la s do s modalidade s clásica s d e democracia , l a representat iv a y l a directa , a la s qu e s e añadirí a l a democraci a pa r ticipat iv (...) a prom o vid a po r lo s ciudadanos, ind i vidualment e o e n gr upo , a l ma r ge n d e lo s pa r tido s políticos . L a resultant e serí a un nu evo marc o polític o co n meno s democraci a representat iva (l a d e lo s pa r tido s político s y lo s representante s electos) , q u e actualment e e s l a democraci a e xclus iva y e xclu y ent e en la s sociedade s política s a v anzadas , má s democraci a direct a (l a d e lo s ciudadano s qu e sin inte r mediario s v otaría n política s y n o sól o a su s representantes ) y u n nu evo espaci o polític o ocupad o po r lo s ciudadanos-actore s político s si n militanci a pa r tidista . E n cad a uno d e esto s tre s modelo s democrático s s e analiz a l a de f inició n de l modelo , e l escenari o que actualment e atr a vies a y la s propuesta s concreta s d e cambio. (shrink)

En este breve comentario discuto algunos aspectos de la interpretación de la epistemología de Davidson que sugiere Willian Duica en su reciente libro. Luego de una presentación somera del libro me centro en tres asuntos centrales de la interpretación de Duica. En primer lugar, argumento que su lectura de la crítica de Davidson al dualismo esquema/contenido es muy restrictiva y deja abierta la posibilidad de un realismo directo empirista. En segundo lugar, argumento que en su lectura el propio Duica se (...) compromete inadvertidamente con un empirismo de este tipo y, de este modo, su interpretación entra en tensión con el coherentismo de Davidson. Finalmente, discuto algunos aspectos de la interpretación que hace Duica de la tesis davidsoniana de la triangulación. In this short comment I discuss some aspects of William Duica's interpretation of Davidson's epistemology in a recent book. After a brief review of the book, I focus on three central issues of Duica's interpretation. First, I argue that his reading of Davidson's criticism of the scheme/content dualism is too restrictive and leaves open the possibility of an empiricist direct realism. Second, I argue in his reading Duica inadvertently commits himself to an empiricism of this sort and, as a result, his interpretation is in tension with Davidson's own coherentism. Finally, I discuss some aspects of Duica's interpretation of Davidsonian triangulation. (shrink)

Este trabajo tiene por objeto el estudio de la agravante de discriminación por razón de género recogida en el art. 22.4ª del C.P, por la Ley Orgánica 1/2015, de 30 de marzo. Nos vamos a centrar en el estudio del fundamento y elementos de la circunstancia agravante. Se prosigue, con el análisis de su compatibilidad con otras agravantes genéricas y su régimen de comunicabilidad a los partícipes del delito. Sin olvidar, el examen de las sentencias dictadas por el Tribunal Supremo.

Este trabajo se centra en la crítica que Martín Diego Farrell, un ilustre filósofo del derecho argentino, dirige al utilitarismo y a su argumento fundamental, la restricción de la libertad en aras de una mayor utilidad. Es una crítica al utilitarismo sobre la que considero que es necesario reflexionar, pues constituye el punto de partida del abandono del utilitarismo por parte de muchos pensadores liberales actuales. Y es también, en mi opinión, el inicio de un peligroso camino hacia un relativismo (...) extremo. He escogido a Martín Diego Farrell como paradigma para plantear algunos problemas actuales de los liberalismos. La autora considera que la filosofía de éste filósofo y jurista argentino es un síntoma claro de la evolución que se produjo dentro del liberalismo, sobre todo desde principios del siglo XX, hacia dos caminos diferenciados, e incluso opuestos, que será necesario subrayar y esclarecer. Desde este análisis podremos comprobar que, cuando hablamos de ciertos neoliberalismos, estamos hablando en realidad de teorías que dejan a un lado las auténticas raíces del liberalismo. (shrink)

Por razones de eficacia (cohesión social, comunidad cívica) y, unidas a ellas, por razones éticas (valores de libertad, igualdad y solidaridad) la propuesta normativa de nuestro tiempo debe ser la universalización de la democracia. No hay futuro para nadie si no se avanza en ella, en la universalización de los derechos humanos, en su protección y realización efectiva en esa escala. Frente a los hechos que impone hoy el neoliberalismo conservador y la muy desigual globalización realmente existente, deben prevalecer los (...) derechos que derivan de la filosofía ética, política y jurídica de la democracia. Su expresión institucional -se estima aquí- es aquella que se concreta en la fórmula o paradigma del Estado social y democrático de Derecho: es decir, un Estado de importante intervención cualitativa; una sociedad civil más y mejor vertebrada, de trama más ajustada, más inclusiva de los nuevos movimientos sociales (feministas, ecologistas, antixenófobos, etc.); un sistema económico mixto, con sector público estatal y social donde el mercado y el sector privado encuentren coherente articulación; todo ello para la protección y realización de los derechos humanos civiles y políticos, económicos, sociales y culturales, así como los nuevos derechos fundamentales de las minorías, los derivados de las diferencias personales y sociales (étnicas, sexuales...), del medio ambiente, etc. En definitiva la razón de ser del Estado de Derecho es la protección y realización efectiva de los derechos humanos. La universalización de éstos y de la democracia exige, pues, la universalización del Estado social y democrático de Derecho. (shrink)

A widespread need to explain the behavior and outcomes of AI-based systems has emerged, due to their ubiquitous presence. Thus, providing renewed momentum to the relatively new research area of eXplainable AI (XAI). Nowadays, the importance of XAI lies in the fact that the increasing control transference to this kind of system for decision making -or, at least, its use for assisting executive stakeholders- already affects many sensitive realms (as in Politics, Social Sciences, or Law). The decision-making power handover to (...) opaque AI systems makes mandatory explaining those, primarily in application scenarios where the stakeholders are unaware of both the high technology applied and the basic principles governing the technological solutions. The issue should not be reduced to a merely technical problem; the explainer would be compelled to transmit richer knowledge about the system (including its role within the informational ecosystem where he/she works). To achieve such an aim, the explainer could exploit, if necessary, practices from other scientific and humanistic areas. The first aim of the paper is to emphasize and justify the need for a multidisciplinary approach that is beneficiated from part of the scientific and philosophical corpus on Explaining, underscoring the particular nuances of the issue within the field of Data Science. The second objective is to develop some arguments justifying the authors’ bet by a more relevant role of ideas inspired by, on the one hand, formal techniques from Knowledge Representation and Reasoning, and on the other hand, the modeling of human reasoning when facing the explanation. This way, explaining modeling practices would seek a sound balance between the pure technical justification and the explainer-explainee agreement. (shrink)

Are emotions bodily feelings or evaluative cognitions? What is happiness, pain, or “being moved”? Are there basic emotions? In this chapter, I review extant empirical work concerning these and related questions in the philosophy of emotion. This will include both (1) studies investigating people’s emotional experiences and (2) studies investigating people’s use of emotion concepts in hypothetical cases. Overall, this review will show the potential of using empirical research methods to inform philosophical questions regarding emotion.

A recent quarrel over faultless disagreements assumes that disputes over evaluative sentences should be understood as regular, factual disagreements. Instead, I propose that evaluative disagreements should be understood in Lewisian terms. Language use works like a rule-governed game. In it, the assertion of an evaluative sentence is an attempt to establish one value as default in the conversation; its rejection, in turn, is in most cases the refusal to accept this move.

El artículo indaga en la reemergencia de ciertos principios que la Edad Media vinculó al pensamiento de Averroes en pensadores contemporáneos como Giorgio Agamben, Roberto Esposito, Emanuele Coccia y Jean Baptiste Brenet. La eternidad del mundo y la separación del itnelecto vuelven a aparecer como sustento de una filosofía capaz de poner en tela de juicio ideas fundamentales de la modernidad como la de sujeto o persona, sin por ello entramparse en el nihilismo.